Discovery of [18F]-MK-6240: A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have [...]
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have [...]
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified [...]
Lactate dehydrogenase (LDH) is an essential metabolic enzyme that catalyzes [...]
Deficiency of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) leads to [...]
BACKGROUND: Amyloid plaques and neurofibrillary tangles (NFTs) are the defining [...]
Regional glucose hypometabolism is a defining feature of Alzheimer disease [...]
Background: The abnormal hyperphosphorylation of the microtubule-associated protein tau plays a [...]
The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine [...]
Alzheimer disease (AD) is a growing problem for aging populations [...]
The inherited deficiency of the lysosomal glucocerebrosidase (GBA) due to [...]