Discovery of [18F]-MK-6240: A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have [...]
O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson’s disease
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified [...]
Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms
Lactate dehydrogenase (LDH) is an essential metabolic enzyme that catalyzes [...]
Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity
Deficiency of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) leads to [...]
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
BACKGROUND: Amyloid plaques and neurofibrillary tangles (NFTs) are the defining [...]
The emerging link between O-GlcNAc and Alzheimer disease
Regional glucose hypometabolism is a defining feature of Alzheimer disease [...]
Chronic O-β-N-acetylglucosaminylase inhibition with Thiamet-G prevents tau pathology and hyperactivity in rTg4510 mice
Background: The abnormal hyperphosphorylation of the microtubule-associated protein tau plays a [...]
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway
The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine [...]
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer’s disease and beyond
Alzheimer disease (AD) is a growing problem for aging populations [...]
Glucocerebrosidase 2 Gene Deletion Rescues Type 1 Gaucher Disease
The inherited deficiency of the lysosomal glucocerebrosidase (GBA) due to [...]