O-GlcNAcylation of TDP-43 Suppresses Proteinopathies and Promotes TDP-43’s mRNA Splicing Activity
Pathological TDP-43 aggregation is characteristic of several neurodegenerative diseases, including [...]
Pathological TDP-43 aggregation is characteristic of several neurodegenerative diseases, including [...]
O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is notably decreased in Alzheimer's disease (AD) [...]
The dopamine system in the midbrain is essential for volitional [...]
Deposition of hyperphosphorylated and aggregated tau protein in the central [...]
Inhibition of O-GlcNAcase (OGA) has emerged as a promising therapeutic [...]
Niemann-Pick type C disease (NPCD) is a neurodegenerative disease associated [...]
Mucolipidosis type IV (MLIV) is a lysosomal storage disease exhibiting [...]
Huntington's disease (HD) is caused by an expanded CAG repeat [...]
[18F]MK-8553 is a high affinity, selective OGA inhibitor with properties [...]
The enzyme glucocerebrosidase (GBA) hydrolyses glucosylceramide (GlcCer) in lysosomes. Markedly [...]