O-GlcNAcylation Regulates Dopamine Neuron Function, Survival and Degeneration in Parkinson Disease
The dopamine system in the midbrain is essential for volitional [...]
The dopamine system in the midbrain is essential for volitional [...]
Deposition of hyperphosphorylated and aggregated tau protein in the central [...]
Inhibition of O-GlcNAcase (OGA) has emerged as a promising therapeutic [...]
Niemann-Pick type C disease (NPCD) is a neurodegenerative disease associated [...]
Mucolipidosis type IV (MLIV) is a lysosomal storage disease exhibiting [...]
[18F]MK-8553 is a high affinity, selective OGA inhibitor with properties [...]
The enzyme glucocerebrosidase (GBA) hydrolyses glucosylceramide (GlcCer) in lysosomes. Markedly [...]
Advances Novel Tau-directed Strategy for Treating Neurodegenerative Disease Phase 1 [...]
Apr 18, 2016 – Alectos Therapeutics partner Merck, known as MSD [...]
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have [...]