NPC – Alectos Therapeutics

Cytosolic Glucosylceramide Regulates Endolysosomal Function in Niemann-Pick type C Disease

Niemann-Pick type C disease (NPCD) is a neurodegenerative disease associated [...]

Administrator2019-03-12T01:50:21-07:00March 12, 2019|Categories: Publications|Tags: GBA2, lysosomal dysfunction, NPC|

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

The enzyme glucocerebrosidase (GBA) hydrolyses glucosylceramide (GlcCer) in lysosomes. Markedly [...]

Administrator2016-06-01T23:22:06-07:00June 1, 2016|Categories: News, Publications|Tags: GBA2, lysosomal dysfunction, NPC|