The Discovery and Characterization of [18F]MK‐8553, a Novel PET Tracer for Imaging O‐GlcNAcase (OGA)
[18F]MK-8553 is a high affinity, selective OGA inhibitor with properties [...]
[18F]MK-8553 is a high affinity, selective OGA inhibitor with properties [...]
The enzyme glucocerebrosidase (GBA) hydrolyses glucosylceramide (GlcCer) in lysosomes. Markedly [...]
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have [...]
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified [...]
Lactate dehydrogenase (LDH) is an essential metabolic enzyme that catalyzes [...]
Deficiency of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) leads to [...]
BACKGROUND: Amyloid plaques and neurofibrillary tangles (NFTs) are the defining [...]
Regional glucose hypometabolism is a defining feature of Alzheimer disease [...]
Background: The abnormal hyperphosphorylation of the microtubule-associated protein tau plays a [...]
The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine [...]