Structural snapshots of the reaction coordinate for O-GlcNAc transferase
Visualization of the reaction coordinate undertaken by glycosyltransferases has remained [...]
Alectos Supports NSERC Funding for Prof. B.M. Pinto at SFU
July 16, 2012 – Alectos today announced its support for [...]
Alectos Supports NSERC Funding for Prof. L. Craig at SFU
April 30, 2012 – Alectos today announced its support for [...]
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
Oligomerization of tau is a key process contributing to the [...]
Insights into O-linked N-acetylglucosamine ((0-9)O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates
Cellular O-linked N-acetylglucosamine (O-GlcNAc) levels are modulated by two enzymes: [...]
Alectos Supports NSERC Funding for Prof. R.A. Britton at SFU
Feb 1, 2012 – Alectos today announced its support for [...]
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells
Glycosyltransferases are ubiquitous enzymes that catalyze the assembly of glycoconjugates [...]
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis
The O-GlcNAc modification is proposed to be a nutrient sensor [...]
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes
To probe increased O-GlcNAc levels as an independent mechanism governing [...]
Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody
The microtubule-associated protein tau is known to be post-translationally modified [...]