Visualizing the reaction coordinate of an O-GlcNAc hydrolase
N-Acetylglucosamine beta-O-linked to serine and threonine residues of nucleocytoplasmic proteins [...]
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance
The O-GlcNAc post-translational modification is considered to act as a [...]
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
Pathological hyperphosphorylation of the microtubule-associated protein tau is characteristic of [...]
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation
N-Acetylglucosamine (O-GlcNAc) modification of proteins provides a mechanism for the [...]
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise
O-GlcNAcase catalyzes the cleavage of beta-O-linked 2-acetamido-2-deoxy-beta-d-glucopyranoside (O-GlcNAc) from serine [...]
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity
O-GlcNAc is an abundant post-translational modification of serine and threonine [...]
Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants
O-GlcNAcase is a family 84 beta-N-acetylglucosaminidase catalyzing the hydrolytic cleavage [...]
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors
The post-translational modification of serine and threonine residues of nucleocytoplasmic [...]