Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells
Glycosyltransferases are ubiquitous enzymes that catalyze the assembly of glycoconjugates [...]
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis
The O-GlcNAc modification is proposed to be a nutrient sensor [...]
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes
To probe increased O-GlcNAc levels as an independent mechanism governing [...]
Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody
The microtubule-associated protein tau is known to be post-translationally modified [...]
Visualizing the reaction coordinate of an O-GlcNAc hydrolase
N-Acetylglucosamine beta-O-linked to serine and threonine residues of nucleocytoplasmic proteins [...]
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance
The O-GlcNAc post-translational modification is considered to act as a [...]
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
Pathological hyperphosphorylation of the microtubule-associated protein tau is characteristic of [...]
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation
N-Acetylglucosamine (O-GlcNAc) modification of proteins provides a mechanism for the [...]
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise
O-GlcNAcase catalyzes the cleavage of beta-O-linked 2-acetamido-2-deoxy-beta-d-glucopyranoside (O-GlcNAc) from serine [...]
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity
O-GlcNAc is an abundant post-translational modification of serine and threonine [...]