[18F]MK-8553 is a high affinity, selective OGA inhibitor with properties suitable for imaging OGA and determining central enzyme occupancy in both preclinical and clinical studies. Currently [18F]MK‐8553 is being utilized in humans as a PET tracer to assess CNS target engagement to select a dose for clinical proof of concept trials with a small molecule OGA inhibitor. The target engagement data generated with [18F]MK‐8553 will ensure proper testing of the OGA mechanism and increase the probability of a successful clinical trial with OGA inhibitors.

Source: Li, W. et al. NRM2016 Presentation.