Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

Lactate dehydrogenase (LDH) is an essential metabolic enzyme that catalyzes the interconversion of pyruvate and lactate using NADH/NAD(+) as a co-substrate. Many cancer cells exhibit a glycolytic phenotype known as the Warburg effect, in which elevated LDH levels enhance the conversion of glucose to lactate, making LDH an attractive therapeutic target for oncology. Two known [...]

January 23rd, 2015|Tags: , , , |

Alectos Supports NSERC Funding for Prof. L. Craig at SFU

April 30, 2012 – Alectos today announced its support for NSERC funding for the group of Prof. L. Craig at Simon Fraser University, Department of Molecular Biology and Biochemistry, in a project titled “Structural analysis of small molecule inhibitors of a novel target for the treatment of cancer". Compared to normal cells, cancer cells exhibit [...]

April 30th, 2012|Tags: , , , |