Dr Bridger co-founded AnorMED Inc. and served as Vice President of Research and Development and Chief Scientific Officer. He was responsible for research, development, and clinical programs within AnorMED; a leading company in the development of chemokine receptor inhibitors for a variety of disease applications. He was responsible for the development of AMD3100 (plerixafor, Mozobil™), a new stem cell mobilizing agent for treatment of multiple myeloma and non-hodgkins lymphoma patients, including the design and completion of two randomized Phase 3 clinical trials. In late 2006, AnorMED was acquired by Genzyme for US $600 million and Mozobil was approved by the US FDA in 2008. In June 2010, Dr. Bridger became a Ventures Partner at Ventures West, an active venture capital partner that invests in early stage technology companies. Dr. Bridger is named inventor on 34 granted US patents and is an author of more than 80 scientific publications.
Dr. Davies is a leading expert in the structural biology of carbohydrate processing enzymes. His research interests are in the use of X-ray crystallography and enzymology to study the biology of carbohydrate processing enzymes and their accessory domains. He has advanced the conformational pathways harnessed by enzymes to effect catalysis and noted how this knowledge can be used to design inhibitors. Dr. Davies has published over 200 scientific papers.
Dr. Gong investigates the molecular mechanisms of neurodegeneration in various brain diseases, especially in Alzheimer’s disease. He has made significant contributions to the understanding of the role of protein phosphatases in Alzheimer’s disease and other tauopathies. He was the first to demonstrate a down-regulation of protein phosphatase 2A in Alzheimer’s brains and its role in the abnormal hyperphosphorylation of tau and neurofibrillary degeneration. He has forwarded a hypothesis explaining the mechanism by which impaired brain glucose uptake contributes to neurodegeneration. Dr. Gong is a leading expert in Alzheimer’s disease, neurodegeneration, protein phosphorylation, protein glycosylation, and signal transduction. He has authored over 90 scientific publications.
His current research is focused on the design and use of novel pharmacological probes and proof of concept molecules for the discovery and validation of new drug targets. He is also director of the Division of Medicinal Chemstry of the Center for Drug Research and Development (CDRD) in British Columbia and consults for a number of Pharmaceutical companies. Dr. Young’s career has focused on the design and synthesis of novel drugs for asthma, inflammation, osteoporosis and related diseases and he is most noted for his part in the discovery of the asthma drug, Singulair™. Dr. Young is a member of the Order of Canada and a Fellow of the Royal Society of Canada, and his academic and professional honours and affiliations are numerous. Dr. Young is an author of more than 160 publications, review articles and patents.