{"id":970,"date":"2014-05-22T21:48:03","date_gmt":"2014-05-22T21:48:03","guid":{"rendered":"http:\/\/alectos.com\/content\/?p=286"},"modified":"2014-05-22T21:48:03","modified_gmt":"2014-05-22T21:48:03","slug":"alectos-preclinical-data-ogt-cancer","status":"publish","type":"post","link":"https:\/\/alectos.com\/alectos-content\/index.php\/2014\/05\/22\/alectos-preclinical-data-ogt-cancer\/","title":{"rendered":"Alectos Announces Preclinical Data for Novel Cancer Metabolism Target"},"content":{"rendered":"<p><strong>May 22, 2014<\/strong> \u2013 Alectos today announced publication of preclinical studies showing that both knockdown and pharmacological inhibition of O-GlcNAc transferase (OGT) result in reduced metabolic output, increased apoptosis, and impaired survival in tumor cells.\u00a0 This data strongly supports OGT as a novel cancer metabolism target.<\/p>\n<p>For details, see: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24857547\" target=\"_blank\" rel=\"noopener\">Ferrer, C.M. et al.<em> Mol Cell<\/em> <strong>54<\/strong>, 820-31 (2014).<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>May 22, 2014 \u2013 Alectos today announced publication of preclinical  [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[30],"tags":[26,27,21,20],"class_list":["post-970","post","type-post","status-publish","format-standard","hentry","category-news","tag-ac-5sglcnac","tag-cancer-metabolism","tag-ogt","tag-sfu"],"_links":{"self":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts\/970","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/comments?post=970"}],"version-history":[{"count":0,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts\/970\/revisions"}],"wp:attachment":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/media?parent=970"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/categories?post=970"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/tags?post=970"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}