{"id":274,"date":"2014-10-26T19:34:28","date_gmt":"2014-10-26T19:34:28","guid":{"rendered":"http:\/\/alectos.com\/content\/?p=274"},"modified":"2014-10-26T19:34:28","modified_gmt":"2014-10-26T19:34:28","slug":"alectos-preclinical-mouse-alzheimers","status":"publish","type":"post","link":"https:\/\/alectos.com\/alectos-content\/index.php\/2014\/10\/26\/alectos-preclinical-mouse-alzheimers\/","title":{"rendered":"Alectos Announces Preclinical Results in TAPP Mouse Model of Alzheimer&#8217;s Disease"},"content":{"rendered":"<p><strong>Oct 26, 2014<\/strong> \u2013 Alectos today announced publication of preclinical studies showing that pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in the TAPP mouse model of Alzheimer\u2019s disease.<\/p>\n<p>For details, see: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25344697\" target=\"_blank\" rel=\"noopener\">Yuzwa, S.A. et al. <em>Mol Neurodegener<\/em> <strong>9<\/strong>:42 (2014).<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oct 26, 2014 \u2013 Alectos today announced publication of preclinical  [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[30],"tags":[22,36,39,18,20,40,24,25],"class_list":["post-274","post","type-post","status-publish","format-standard","hentry","category-news","tag-alzheimers","tag-amyloid","tag-nfts","tag-oga","tag-sfu","tag-tapp","tag-tau","tag-thiamet-g"],"_links":{"self":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts\/274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/comments?post=274"}],"version-history":[{"count":0,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts\/274\/revisions"}],"wp:attachment":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/media?parent=274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/categories?post=274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/tags?post=274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}