{"id":174,"date":"2008-06-08T00:46:11","date_gmt":"2008-06-08T00:46:11","guid":{"rendered":"http:\/\/alectos.com\/content\/?p=174"},"modified":"2008-06-08T00:46:11","modified_gmt":"2008-06-08T00:46:11","slug":"ogt-homolog-insight-glycosylation","status":"publish","type":"post","link":"https:\/\/alectos.com\/alectos-content\/index.php\/2008\/06\/08\/ogt-homolog-insight-glycosylation\/","title":{"rendered":"Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation"},"content":{"rendered":"<p>N-Acetylglucosamine (O-GlcNAc) modification of proteins provides a mechanism for the control of diverse cellular processes through a dynamic interplay with phosphorylation. UDP-GlcNAc:polypeptidyl transferase (OGT) catalyzes O-GlcNAc addition. The structure of an intact OGT homolog and kinetic analysis of human OGT variants reveal a contiguous superhelical groove that directs substrates to the active site.<\/p>\n<p>Source: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18536723\" target=\"_blank\" rel=\"noopener\">Martinez-Fleites, C. et al. <em>Nat Struct Mol Biol<\/em> <strong>15<\/strong>, 764-5 (2008).<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>N-Acetylglucosamine (O-GlcNAc) modification of proteins provides a mechanism for the  [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[19],"tags":[21,20],"class_list":["post-174","post","type-post","status-publish","format-standard","hentry","category-publications","tag-ogt","tag-sfu"],"_links":{"self":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts\/174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/comments?post=174"}],"version-history":[{"count":0,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/posts\/174\/revisions"}],"wp:attachment":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/media?parent=174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/categories?post=174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/tags?post=174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}