{"id":590,"date":"2016-11-01T15:40:04","date_gmt":"2016-11-01T15:40:04","guid":{"rendered":"https:\/\/alectos.com\/alectos-content\/?page_id=13"},"modified":"2022-05-12T04:09:45","modified_gmt":"2022-05-12T04:09:45","slug":"publications","status":"publish","type":"page","link":"https:\/\/alectos.com\/alectos-content\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Publications<\/h2><\/div>
<\/div><\/div><\/div><\/div>
\n

O-GlcNAcylation: a pro-survival response to acute stress in the cardiovascular and central nervous systems<\/a><\/h2>

O-GlcNAcylation is a unique monosaccharide modification that is ubiquitously present in numerous nucleoplasmic and mitochondrial proteins. The hexosamine biosynthesis pathway (HBP), which is a key branch of glycolysis, provides the unique sugar donor UDP-GlcNAc for [...]<\/p><\/div><\/div>

<\/div>
Administrator<\/a><\/span><\/span>2025-03-27T13:00:36-07:00<\/span>March 27, 2025<\/span>|<\/span><\/div>
Read More<\/a><\/div><\/div><\/article>\n
\n

O-GlcNAcylation and Its Roles in Neurodegenerative Diseases<\/a><\/h2>

As a non-classical post-translational modification, O-linked \u03b2-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is widely found in human organ systems, particularly in our brains, and is indispensable for healthy cell biology. With the increasing age of the global [...]<\/p><\/div><\/div>

<\/div>
Administrator<\/a><\/span><\/span>2025-03-27T12:55:58-07:00<\/span>March 27, 2025<\/span>|<\/span><\/div>
Read More<\/a><\/div><\/div><\/article>\n
\n

O-GlcNAcylation of TDP-43 Suppresses Proteinopathies and Promotes TDP-43’s mRNA Splicing Activity<\/a><\/h2>

Pathological TDP-43 aggregation is characteristic of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP); however, how TDP-43 aggregation and function are regulated remain poorly understood. Here, we show that O-GlcNAc [...]<\/p><\/div><\/div>

<\/div>
Administrator<\/a><\/span><\/span>2022-05-18T02:05:29-07:00<\/span>April 15, 2021<\/span>|<\/span><\/div>
Read More<\/a><\/div><\/div><\/article>\n
\n

O-GlcNAcylation Ameliorates the Pathological Manifestations of Alzheimer’s Disease by Inhibiting Necroptosis<\/a><\/h2>

O-GlcNAcylation (O-linked \u03b2-N-acetylglucosaminylation) is notably decreased in Alzheimer's disease (AD) brain. Necroptosis is activated in AD brain and is positively correlated with neuroinflammation and tau pathology. However, the links among altered O-GlcNAcylation, \u03b2-amyloid (A\u03b2) accumulation, [...]<\/p><\/div><\/div>

<\/div>
Administrator<\/a><\/span><\/span>2022-05-18T18:35:31-07:00<\/span>January 13, 2021<\/span>|<\/span><\/div>
Read More<\/a><\/div><\/div><\/article>\n<\/div>
1<\/span>2<\/a>Next<\/span><\/span><\/a><\/div>
<\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-590","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/pages\/590","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/comments?post=590"}],"version-history":[{"count":12,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/pages\/590\/revisions"}],"predecessor-version":[{"id":1001,"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/pages\/590\/revisions\/1001"}],"wp:attachment":[{"href":"https:\/\/alectos.com\/alectos-content\/index.php\/wp-json\/wp\/v2\/media?parent=590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}