Sweet relief: the Parkinson’s disease-associated protein α-synuclein is post-translationally modified by N-acetylglucosamine (O-GlcNAc), but the biochemical consequences are unknown. Here we show that an O-GlcNAc-modified peptide does not participate in α-synuclein aggregation, thus suggesting that O-GlcNAc might directly inhibit aggregation in cells.

Source: Marotta, N.P. et al. Chembiochem 13(18), 2665-2670 (2012).